Abundance of Lactobacillus in porcine gut microbiota is closely related to immune response following PRRSV immunization

文献类型： 外文期刊

第一作者： Zhang, He

作者： Zhang, He;Ma, Wenjie;Werid, Gebremeskel Mamu;Ibrahim, Yassein M.;Zhang, Wenli;Pan, Yu;Chen, Hongyan;Wang, Yue;Zhang, He;Shi, Dongfang;Sun, Zhi;Zhu, Changkang

作者机构：

关键词： Gut microbiota; PRRSV; Immune response; Lactobacillus

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2021 年 259 卷

页码：

收录情况： SCI

摘要： Increasing evidence shows that gut microbiota plays a critical role in host immune system development and immune regulation, thus the composition of gut microbiota may affect how individuals respond to immunizations. Currently, little evidence is available on the correlation between porcine gut microbiota and vaccine immune response. Here, we investigated the influence of gut microbiota on immune response in pigs to porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Based on the antibody levels for PRRSV, the immunized pigs were divided into three groups (high, low, and others), and followed by virulent PRRSV challenge. The comprehensive analysis of microbial composition revealed that gut microbiota was similar in the richness and diversity among different groups before immunization. After immunization, the richness and diversity of gut microbial community in the high group were still similar to the low group, although there was a decrease in community diversity overtime. Interestingly, the antibody titer was positively correlated with the abundance of Lactobacillus in gut microbiota in immunized pigs. Further analysis indicated that gut microbial composition might be correlated to the clinical parameters such as body weight and rectal temperature after virus challenge. Taken together, our findings suggest that certain specific members of gut microbiota, such as Lactobacillus may serve as a mechanism for regulating the immune response following immunization in pigs.

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