The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense

文献类型： 外文期刊

第一作者： Zhao, Shuangzhi

作者： Zhao, Shuangzhi;Xu, Hui;Suvorov, Alexander;Wang, Junhua;Qiu, Jiying;Zhou, Qingxin;Yang, Jinyu;Chen, Leilei;Zhao, Shuangzhi;Lei, Ming;He, Hailun

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关键词： Ganoderma amboinense mycelium; polysaccharide; Proliferation promotion; Wound healing; Antioxidant activity

期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：5.154； ）

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年卷期： 2021 年 10 卷 4 期

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收录情况： SCI

摘要： To study the cell proliferation and wound healing activity of polysaccharides from Ganoderma amboinense (GAMPS), the polysaccharide was extracted by water extraction and alcohol precipitation method, and its monosaccharide composition and molecular weight were analyzed. The effects of different concentrations of GAMPS on the cell proliferation were determined by cell survival rate test, and the wound healing ability of GAMPS to NIH/3T3 cells was detected. The preliminary evaluation of the antioxidant ability of GAMPS was conducted by the oxygen radical absorbance capacity (ORAC). The results showed that the GAMPS was composed of glucose, mannose, and galactose at a molar ratio of 67.62:14.07:7.50, and the weight-average molecular weights were 5.439 x 10(6) and 1.704 x 10(5) g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter (HPGPC-MALS) analysis. GAMPS (0.2 mu g/mu L) showed the strongest proliferation ability to THP-1 cells, with cell survival rate of 178.7%. The wound healing effect of GAMPS (0.1 mu g/mu L) was obvious on NIH/3T3 and 3.75 mu g/mu L of GAMPS showed the strongest total antioxidant ability. All the results indicate that GAMPS promotes cell proliferation, and has cell wound healing effect and strong antioxidant activity. The results provide theoretical foundation for the development and utilization of GAMPS. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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[1]The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense. Zhao, Shuangzhi,Xu, Hui,Suvorov, Alexander,Wang, Junhua,Qiu, Jiying,Zhou, Qingxin,Yang, Jinyu,Chen, Leilei,Zhao, Shuangzhi,Lei, Ming,He, Hailun. 2021

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