Three in One with Dual-Functional Hydrogel of Lactoferrin/NZ2114/LMSH Promoting Staphylococcus aureus-Infected Wound Healing

文献类型： 外文期刊

第一作者： Zhang, Kun

作者： Zhang, Kun;Ma, Xuanxuan;Teng, Da;Mao, Ruoyu;Yang, Na;Hao, Ya;Wang, Jianhua;Zhang, Kun;Ma, Xuanxuan;Teng, Da;Mao, Ruoyu;Yang, Na;Hao, Ya;Wang, Jianhua;Zhang, Kun;Ma, Xuanxuan;Teng, Da;Mao, Ruoyu;Yang, Na;Hao, Ya;Wang, Jianhua

作者机构：

关键词： injectable hydrogel; Lf/NZ2114/LMSH (Three in One); would dressing; Staphylococcus aureus infection

期刊名称：ANTIBIOTICS-BASEL （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN： 2079-6382

年卷期： 2024 年 13 卷 9 期

页码：

收录情况： SCI

摘要： Wound infections caused by Staphylococcus aureus often result in localized suppurative lesions that severely impede the healing process, so it is urgent to develop a dress with efficient antimicrobial and pro-healing functions. In this study, the bifunctional injectable hydrogel lactoferrin (Lf)/NZ2114/lithium magnesium silicate hydrogel (LMSH) was first successfully prepared through the electrostatic interaction method. The physical, biological, and efficacy properties are systematically analyzed with good shear-thinning capacity and biocompatibility. More importantly, it inhibits infection and promotes wound healing in a mouse wound infection model after 14 d treatment, and the bactericidal rate and healing rate were over 99.92% and nearly 100%, respectively. Meanwhile, the massive reduction of inflammatory cells, restoration of tissue structure, and angiogenesis in mice showed the anti-inflammatory and pro-healing properties of the hydrogel. The healed wounds showed thickening with more hair follicles and glands, suggesting that the hydrogel Lf/NZ2114/LMSH (Three in One) could be a better dressing candidate for the treatment of S. aureus-induced wound infections.

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