Novel mangiferin derivatives attenuate adipogenesis in 3T3-L1 preadipocytes and ameliorate diet induced obesity in C57BL/6J mice

文献类型： 外文期刊

第一作者： Gu, Dong-Quan

作者： Gu, Dong-Quan;Li, Yin;Wu, Liu-Shun;Lyu, Meng-Ting;Li, Ying;Xu, Feng-Qing;Wu, De-Ling;Zhou, Wu-Xi;Xu, Feng-Qing;Wu, De-Ling;Zhou, Wu-Xi;Xu, Feng-Qing;Wu, De-Ling;Huang, Sheng-Zhuo

作者机构：

期刊名称：RSC MEDICINAL CHEMISTRY （ 影响因子：3.6； 五年影响因子：4.2 ）

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年卷期： 2025 年

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收录情况： SCI

摘要： Mangiferin with a xanthone scaffold exhibited potent anti-obesity activities and thus has attracted interest. However, some shortcomings, including limited solubility and moderate potency, restrict its application. To develop novel and efficient anti-obesity agents, a series of mangiferin (MGF) amino acid derivatives were synthesized, optimized and evaluated for anti-obesity activities in vitro and in vivo. Among these derivatives, G1 was identified to be a promising compound. G1 showed better liposolubility compared to MGF. In 3T3-L1 preadipocytes, G1 significantly inhibited cell differentiation and reduced fat accumulation by increasing inhibitory activity on fatty acid synthase, and triggering G0/G1 phase cell cycle arrest and production of intracellular reactive oxygen species. The intraperitoneal administration of G1 (30, 60 mg kg-1/2 days) significantly inhibited body, liver and fat tissue weight gain, reduced lipid dysfunction, and ameliorated pathological characteristics in high-fat diet induced C57BL/6J obese mice. These results suggest that compound G1 may warrant further investigation as a promising anti-obesity agent for the treatment of human obesity.

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