文献类型： 外文期刊
第一作者： Chai, Mengzhu
作者： Chai, Mengzhu;Li, Lei;Yang, Yingshuai;Wang, Yuting;Jiang, Xue;Luan, Yameng;Wang, Aiming;Xiang, Wensheng;Wu, Xiaoyun;Cheng, Xiaofei;Li, Yong;Li, Fangfang;Cui, Hongguang;Wang, Aiming
作者机构：
关键词： Potyviridae; viroporin; virus; 6K1
期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：9.4； 五年影响因子：10.8 ）
ISSN： 0027-8424
年卷期： 2024 年 121 卷 21 期
页码：
收录情况： SCI
摘要： Potyviridae, the largest family of plant RNA viruses, includes many important pathogens that significantly reduce the yields of many crops worldwide. In this study, we report that the 6-kilodalton peptide 1 (6K1), one of the least characterized potyviral proteins, is an endoplasmic reticulum-localized protein. AI-assisted structure modeling and biochemical assays suggest that 6K1 forms pentamers with a central hydrophobic tunnel, can increase the cell membrane permeability of Escherichia coli and Nicotiana benthamiana , and can conduct potassium in Saccharomyces cerevisiae. An infectivity assay showed that viral proliferation is inhibited by mutations that affect 6K1 multimerization. Moreover, the 6K1 or its homologous 7K proteins from other viruses of the Potyviridae family also have the ability to increase cell membrane permeability and transmembrane potassium conductance. Taken together, these data reveal that 6K1 and its homologous 7K proteins function as viroporins in viral infected cells.
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