Rice stripe virus nonstructural protein 3 suppresses plant defence responses mediated by the MEL-SHMT1 module

文献类型： 外文期刊

第一作者： Wang, Kun

作者： Wang, Kun;Fu, Shuai;Wu, Liang;Wu, Jianxiang;Wang, Yaqin;Zhou, Xueping;Fu, Shuai;Zhou, Xueping;Xu, Yi;Wang, Yaqin;Zhou, Xueping

作者机构：

关键词： E3 ligase; NS3; plant defence response; Rice stripe virus; SHMT1

期刊名称：MOLECULAR PLANT PATHOLOGY （ 影响因子：4.9； 五年影响因子：5.9 ）

ISSN： 1464-6722

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Our previous study identified an evolutionarily conserved C4HC3-type E3 ligase, named microtubule-associated E3 ligase (MEL), that regulates broad-spectrum plant resistance against viral, fungal and bacterial pathogens in multiple plant species by mediating serine hydroxymethyltransferase (SHMT1) degradation via the 26S proteasome pathway. In the present study, we found that NS3 protein encoded by rice stripe virus could competitively bind to the MEL substrate recognition site, thereby inhibiting MEL interacting with and ubiquitinating SHMT1. This, in turn, leads to the accumulation of SHMT1 and the repression of downstream plant defence responses, including reactive oxygen species accumulation, mitogen-activated protein kinase pathway activation, and the up-regulation of disease-related gene expression. Our findings shed light on the ongoing arms race between pathogens and demonstrate how a plant virus can counteract the plant defence response.

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