Research Note: Metabolic utilization of iron from different iron sources in primary cultured hepatocytes of broiler embryos

文献类型： 外文期刊

第一作者： Hu, Yun

作者： Hu, Yun;Ma, Xuelian;Lu, Lin;Zhang, Liyang;Liao, Xiudong;Hu, Yun;Luo, Xugang

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关键词： chick embryo hepatocyte; iron source; iron-containing enzyme; ferritin

期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）

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年卷期： 2022 年 101 卷 6 期

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收录情况： SCI

摘要： The present study was carried out to evaluate the effects of iron (Fe) sources and levels on the Fe concentration and expressions of iron-containing enzymes or protein in primary cultured hepatocytes of broiler embryos. The hepatocytes were incubated with 0, 0.25 and 0.50 mmol/L added Fe from either Fe sulfate, or 1 of 3 organic Fe chelates with weak (Fe-Met W), moderate (Fe-Pro M), or extremely strong (Fe-Pro ES) chelation strengths for 24 h. The results showed that all supplemental Fe treatments had higher (P < 0.05) Fe concentration, succinate dehydrogenase (SDH), CAT and ferritin heavy chain 1 (FTH1) mRNA levels than those in the control group. The hepatocytes incubated with Fe-Prot ES had lower (P < 0.009) Fe concentration than those incubated with Fe sulfate, Fe-Met W or Fe-Prot M. The SDH mRNA level was lower (P < 0.05) in Fe sulfate and Fe-Prot ES groups than in Fe-Prot M group. In conclusion, the Fe from Fe-Prot ES was less utilizable than Fe from Fe sulfate, FeMet W or Fe-Pro M in primary cultured hepatocytes of broiler embryos.

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