Preparation of multiresponsive hydrophilic molecularly imprinted microspheres for rapid separation of gardenia yellow and geniposide from gardenia fruit

文献类型： 外文期刊

第一作者： Wang, Jinshuang

作者： Wang, Jinshuang;Yu, Ningxiang;Sun, Jingliang;Nie, Xiaohua;Meng, Xianghe;Ye, Qin;Huan, Weiwei

作者机构：

关键词： Gardenia yellow; Geniposide; Molecularly imprinted microspheres; Multiresponsive; Solid phase extraction; Selective separation

期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）

ISSN： 0308-8146

年卷期： 2022 年 374 卷

页码：

收录情况： SCI

摘要： In this work, a robust method for the separation of gardenia yellow and geniposide from gardenia fruit was developed based on a molecularly imprinted solid phase extraction (MISPE) procedure. First, hydrophilic molecularly imprinted microspheres (HMIMs) were prepared using gardenia yellow as the template via reversible addition fragmentation chain transfer (RAFT) precipitation polymerization. The resultant HMIMs demonstrated the multiresponsiveness to pH, temperature, and magnetism, achieving controllable uptake and release of gardenia yellow and easy recovery by external magnets. Meanwhile, the HMIMs possessed high adsorption capacity, fast binding kinetics, specific recognition, and reusability. Finally, a MISPE approach using HMIMs as adsorbent was developed for extraction of gardenia yellow and purification of geniposide after optimization of the adsorption and elution conditions. Thus, efficient separation of gardenia yellow and geniposide with relative purities of 99.77 +/- 0.05% (94.04 +/- 0.10% recovered) and 94.50 +/- 0.62% (95.40 +/- 0.86% recovered), respectively, was achieved.

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