Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

文献类型： 外文期刊

第一作者： Qu, Xiaoqing

作者： Qu, Xiaoqing;Wang, Jian-Hua;Qu, Xiaoqing;Gao, Chenxi;Qiu, Hongdeng;Chen, Jia;Qu, Xiaoqing;Gao, Chenxi;Qiu, Hongdeng;Chen, Jia;Gao, Chenxi;Fu, Lei;Chu, Yuefeng

作者机构：

关键词： positively charged carbon dots; electrostatic interaction; antibacterial; antioxidative; wound healing

期刊名称：ACS APPLIED MATERIALS & INTERFACES （ 影响因子：9.5； 五年影响因子：9.6 ）

ISSN： 1944-8244

年卷期： 2023 年 15 卷 15 期

页码：

收录情况： SCI

摘要： Bacterial infection and excess reactive oxygen species are key factors that lead to slow or substantially delayed wound healing. It is crucial to design and develop new nanomaterials with antibacterial and antioxidative capabilities for wound healing. Here, positively charged carbon dots (CDs) are rationally designed and synthesized from p-phenylenediamine and polyethyleneimine by a facile one-pot solvothermal method, which show good biocompatibility in in vitro cytotoxicity, hemolysis assays, and in vivo toxicity evaluation. The positively charged CDs show superior antimicrobial effect against Staphylococcus aureus (S. aureus) at very low concentrations, reducing the risk of wound infection. At the same time, CDs with surface defects and unpaired electrons can effectively scavenge excess free radicals to reduce oxidative stress damage, accelerate wound inflammation-proliferation transition, and promote wound healing. The mouse model of skin infection demonstrates that CDs can effectively promote the wound healing of skin infection without obvious side effects by simply dropping or spraying onto the wound. We believe that the prepared CDs have satisfactory biocompatibility, antioxidant capacity, and excellent antibacterial activity and have great application potential in wound healing.

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