Gooseberry anthocyanins protect mice hepatic fibrosis by inhibiting TGF-beta/ Smad pathway

文献类型： 外文期刊

第一作者： Yang, Jing

作者： Yang, Jing;Yu, Wenchen;Hao, Ruobing;Wei, Jie;Gao, Jun;Fan, Jungang

作者机构：

关键词： Gooseberry anthocyanins (GA); Hepatic fibrosis; TGF-beta/Smad signaling pathway; Mechanism

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.318； 五年影响因子：5.846 ）

ISSN： 2212-4292

年卷期： 2020 年 37 卷

页码：

收录情况： SCI

摘要： Liver disease is usually caused by oxidative stress and inflammation, leading to an overproduction of extracellular matrix (ECM), which in turn develops into hepatic fibrosis. Gooseberry anthocyanins (GA) are flavonoids with antioxidant, anti-inflammatory and anti-cancer properties. In this study, We evaluated the anti-fibrotic efficacy of GA in mice model of CCl4-induced hepatic fibrosis and explored its underlying mechanisms. Compared with the model group, the treatment group significantly reduced alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD) and reduced glutathione (GSH) content; reduced liver tissue damage; and reduced the TNF-alpha, IL-1, IL-6, COX-2 functions as a marker of inflammation at the transcriptional level; the expression of alpha-SMA protein and collagen I in mice with hepatic fibrosis induced by CCl4 was also inhibited.In terms of mechanism, GA inhibit hepatic fibrosis by the TGF-beta/Smad signaling pathway. In conclusion, this study showed that GA is an effective therapeutic agent for the treatment of liver fibrosis, it also provided a theoretical basis for the anti-fibrosis effect of GA. In the future GA should be considered as promising and important candidates for the treatment of various liver diseases.

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