DDX20: A Multifunctional Complex Protein

文献类型： 外文期刊

第一作者： He, Lu

作者： He, Lu;Yang, Jinke;Hao, Yu;Yang, Xing;Shi, Xijuan;Zhang, Dajun;Zhao, Dengshuai;Yan, Wenqian;Bie, Xintian;Chen, Lingling;Chen, Guohui;Zhao, Siyue;Liu, Xiangtao;Zheng, Haixue;Zhang, Keshan;He, Lu;Yang, Jinke;Hao, Yu;Yang, Xing;Shi, Xijuan;Zhang, Dajun;Zhao, Dengshuai;Yan, Wenqian;Bie, Xintian;Chen, Lingling;Chen, Guohui;Zhao, Siyue;Liu, Xiangtao;Zheng, Haixue;Zhang, Keshan

作者机构：

关键词： DDX20; NF-kappa B; transcription; SMN complexe; cancer; miRNA

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN：

年卷期： 2023 年 28 卷 20 期

页码：

收录情况： SCI

摘要： DEAD-box decapping enzyme 20 (DDX20) is a putative RNA-decapping enzyme that can be identified by the conserved motif Asp-Glu-Ala-Asp (DEAD). Cellular processes involve numerous RNA secondary structure alterations, including translation initiation, nuclear and mitochondrial splicing, and assembly of ribosomes and spliceosomes. DDX20 reportedly plays an important role in cellular transcription and post-transcriptional modifications. On the one hand, DDX20 can interact with various transcription factors and repress the transcriptional process. On the other hand, DDX20 forms the survival motor neuron complex and participates in the assembly of snRNP, ultimately affecting the RNA splicing process. Finally, DDX20 can potentially rely on its RNA-unwinding enzyme function to participate in microRNA (miRNA) maturation and act as a component of the RNA-induced silencing complex. In addition, although DDX20 is not a key component in the innate immune system signaling pathway, it can affect the nuclear factor kappa B (NF-kappa B) and p53 signaling pathways. In particular, DDX20 plays different roles in tumorigenesis development through the NF-kappa B signaling pathway. This process is regulated by various factors such as miRNA. DDX20 can influence processes such as viral replication in cells by interacting with two proteins in Epstein-Barr virus and can regulate the replication process of several viruses through the innate immune system, indicating that DDX20 plays an important role in the innate immune system. Herein, we review the effects of DDX20 on the innate immune system and its role in transcriptional and post-transcriptional modification processes, based on which we provide an outlook on the future of DDX20 research in innate immunity and viral infections.

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