In vitro fermentation characteristics of blueberry anthocyanins and their impacts on gut microbiota from obese human

文献类型： 外文期刊

第一作者： Xu, Lujing

作者： Xu, Lujing;Huang, Wuyang;Tang, Zhaocheng;Qiu, Zeyu;Tang, Zhaocheng;Qiu, Zeyu;Herrera-Balandrano, Daniela D.;Li, Bin;Yang, Yiyun

作者机构： Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China;Jiangsu Acad Agr Sci, Prov Key Lab Agrobiol, Nanjing 210014, Peoples R China;Jiangsu Acad Agr Sci, Inst Germplasm Resources & Biotechnol, Nanjing 210014, Peoples R China;Nantong Univ, Sch Life Sci, Nantong 226007, Peoples R China;Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Liaoning, Peoples R China;Zhejiang Lanmei Technol Co Ltd, Zhuji 311899, Peoples R China

关键词： Blueberry anthocyanins; Fermentation; Degradation; Gut microbiota; Short-chain fatty acids; Obesity

期刊名称：FOOD RESEARCH INTERNATIONAL （ 2022影响因子：8.1； 五年影响因子：7.7 ）

ISSN： 0963-9969

年卷期： 2024 年 176 卷

页码：

收录情况： SCI

摘要： It has been demonstrated that the gut microbiota may play an important intermediary role in anthocyanins' beneficial impacts on obesity. However, the microbe-related anti-obesity mechanism of blueberry anthocyanins remains unclear. In this study, the interactions between blueberry anthocyanin extracts (BAE) and gut microbiota from obese humans were explored using an in vitro fermentation model. Due to hydrolysis and metabolism by the microbiota, the contents of blueberry anthocyanins are reduced during fermentation. It was demonstrated that both aglycones and glycosides affected the degradation rate. The microbial composition evaluation revealed that BAE could alleviate obesity by promoting the colonization of probiotics such as Lachnospiraceae_UCG-004 and Bacteroides, as well as inhibiting the proliferation of harmful bacteria including Escherichia-Shigella, Clostridium_sensu_stricto_1, and Klebsiella. Blueberry anthocyanin extracts facilitate the production of short-chain fatty acids (SCFAs), which is beneficial for obesity control. The relationship between blueberry anthocyanins, gut microbiota, and SCFAs was further investigated. Overall, this data provides new insights into the positive interaction between blueberry anthocyanins and gut microbiota in obese humans.

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