Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-icB signaling pathway

文献类型： 外文期刊

第一作者： Lv, Chaoxiang

作者： Lv, Chaoxiang;Zhang, Qiqi;Qi, Jing;Qin, Tian;Jin, Ningyi;Zhou, Yifa;Lv, Chaoxiang;Li, Yuanguo;Wang, Tiecheng;Qi, Jing;Sima, Mingwei;Li, Entao;Qin, Tian;Shi, Zhuangzhuang;Li, Fangxu;Wang, Xuefeng;Sun, Weiyang;Feng, Na;Yang, Songtao;Xia, Xianzhu;Jin, Ningyi;Gao, Yuwei;Li, Yuanguo;Sima, Mingwei;Jin, Ningyi;Gao, Yuwei;Shi, Zhuangzhuang;Jin, Ningyi;Gao, Yuwei;Li, Fangxu;Gao, Yuwei

作者机构：

关键词： Influenza viruses; Taurolidine (TRD); Cytokine storms; Inflammatory response; NF-icB signaling pathway

期刊名称：VIROLOGICA SINICA （ 影响因子：5.5； 五年影响因子：4.9 ）

ISSN： 1674-0769

年卷期： 2023 年 38 卷 1 期

页码：

收录情况： SCI

摘要： Taurolidine (TRD), a derivative of taurine, has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls, endotoxins and exotoxins to inhibit the adhesion of microorganisms. However, its application in antiviral therapy is seldom reported. Here, we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration (EC50) of 34.45 mu g/mL. Furthermore, the drug inhibited the amplification of the cytokine storm effect and improved the survival rate of mice lethal challenged with H5N1 (protection rate was 86%). Moreover, TRD attenuated virus-induced lung damage and reduced virus titers in mice lungs. Administration of TRD reduced the number of neutrophils and increased the number of lymphocytes in the blood of H5N1 virus-infected mice. Importantly, the drug regulated the NF-icB signaling pathway by inhibiting the separation of NF-icB and IicBa, thereby reducing the expression of inflammatory factors. In conclusion, our findings suggested that TRD could act as a potential anti-influenza drug candidate in further clinical studies.

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