文献类型： 外文期刊
第一作者： Wang, Jing
作者： Wang, Jing;Xing, Baosong;Chen, Junfeng;Zhang, Jiaqing;Ren, Qiaoling;Ma, Qiang;Guo, Hongxia;Yang, Youbing;Lu, Qingxia;Cao, Hai
作者机构：
关键词： castration; circRNA; pig; subcutaneous adipose tissue; testosterone
期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.749； 五年影响因子：1.909 ）
ISSN： 1344-3941
年卷期： 2021 年 92 卷 1 期
页码：
收录情况： SCI
摘要： Circular RNAs (circRNAs) participated in regulation of lipid metabolism; however, its functional role on castration-induced lipid deposition has not been deeply researched. So in this research, we firstly compared circRNAs expressional differences in subcutaneous adipose tissue between intact and castrated male Huainan pigs. A total of 6116 differentially expressed circRNAs (DECs) were detected between these two groups (|log(2)foldchange| >= 1 and p(adj) <= 0.05); GO and KEGG analysis showed that their parent genes were mainly enriched in metabolism-related pathway. And TGF-beta, insulin, AMPK, and MAPK pathways might play vital role in castration-induced lipid deposition. The miRNAs enriched in the constructed circRNA-miRNA network were mainly participated in adipogenesis and lipid metabolism, such as miR-143a-3p, miR-378, and miR-195. And it was verified that testosterone upregulated miR-181a but downregulated circ_0005912 expression in a dose-dependent manner in porcine intramuscular adipocytes, and overexpression of miR-181a inhibited circ_0005912. Taken together, these DECs may participate in the regulation of lipid metabolism after castration by reaction with miRNAs, which indicated the novel role of circRNAs in castration-induced lipid deposition.
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