Bisphenol analogues induced social defects and neural impairment in zebrafish

文献类型： 外文期刊

第一作者： Mu, Xiyan

作者： Mu, Xiyan;Liu, Zaiteng;Zhao, Xiaoyu;Chen, Lu;Jia, Qi;Qiu, Jing;Qian, Yongzhong;Wang, Chengju;Li, Tiejun;Guo, Yuanming

作者机构：

关键词： Bisphenol analogues; Social behavior defect; Neural damage; Zebrafish; Gut-brain transcriptional changes

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 899 卷

页码：

收录情况： SCI

摘要： There is evidence in humans that endocrine disrupting chemicals exposure, such as bisphenol A (BPA), is tied to social behavior impacts when evaluated in early life stage. However, the potential social impact of BPA alternatives and its association with central nervous system (CNS) is poorly understood. Here, we performed behavioral test for zebrafish that are continuously exposed to environmental relevant concentrations (5 and 500 ng/L) of BPA, BPF, and BPAF since embryonic stage. Surprisingly, significant social behavior defects, including increased social distance and decreased contact time, were identified in zebrafish treated by 500 ng/L BPAF and BPA. These behavioral changes were accompanied by apparent histological injury, microglia activation, enhanced apoptosis and neuron loss in brain. The gut-brain transcriptional profile showed that genes involved in neuronal development pathways were up-regulated in all bisphenol analogs treatments, indicating a protective phenotype of CNS; however, these pathways were inhibited in gut. Besides, a variety of key regulators in the gutbrain regulation were identified based on protein interaction prediction, such as rac1-limk1, insrb1 and fosab. These findings implicated that the existence of bisphenol analogues in water would influence the social life of fish, and revealed a potential role of gut-brain transcriptional alteration in mediating this effect.

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