Efficiency of NZ2114 on Superficial Pyoderma Infected with Staphylococcus pseudintermedius

文献类型： 外文期刊

第一作者： Yang, Na

作者： Yang, Na;Huang, Yan;Li, Yuanyuan;Teng, Da;Mao, Ruoyu;Hao, Ya;Wang, Jianhua;Yang, Na;Huang, Yan;Li, Yuanyuan;Teng, Da;Mao, Ruoyu;Hao, Ya;Wang, Jianhua;Yang, Na;Huang, Yan;Li, Yuanyuan;Teng, Da;Mao, Ruoyu;Hao, Ya;Wang, Jianhua;Huang, Yan;Wei, Lingyun

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关键词： antimicrobial peptides; NZ2114; Staphylococcus pseudintermedius; transdermal delivery; chemical permeation enhancers; superficial pyoderma

期刊名称：PHARMACEUTICALS （ 影响因子：4.6； 五年影响因子：4.9 ）

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年卷期： 2024 年 17 卷 3 期

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收录情况： SCI

摘要： Staphylococcus pseudintermedius (S. pseudintermedius) is the main pathogen causing pyoderma of canines. With the emergence of drug-resistant bacteria, traditional antibiotic treatments are limited. As a potential antibacterial agent, NZ2114 was effective against S. pseudintermedius, including drug-resistant strains. Its bactericidal efficacy was superior to mupiroxacin, ofloxacin and lincomycin. To facilitate the transcutaneous delivery of NZ2114 for the treatment of superficial pyoderma, chemical permeation enhancers were added since water-soluble NZ2114 does not easily penetrate the skin lipid layer. Two different NZ2114 sprays were prepared by combining 1% Azone + 10% propylene glycol (PG) or 5% N-methylpyrrolidone (NMP) + 10% PG with NZ2114 after screening. The cumulative permeability of NZ2114 sprays were 244.149 and 405.245 mu g/cm(2) at 24 h with an in vitro percutaneous assay of mice skin, which showed a 244% and 405% increase in skin permeability than NZ2114, respectively. In addition, the efficacy of NZ2114 sprays in reducing skin bacteria colonisation was demonstrated in a mouse model of superficial pyoderma (24 mice, 3 mice/group) induced by S. pseudintermedius, and the 5% NMP + 10% PG + NZ2114 group had the best therapeutic effect compared to the other groups. This preparation did not cause any skin irritation, laying the foundation for the development of an effective and non-toxic topical product.

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