Identification of miR-71*as a regulator of Flotillin-1 in egg development of Rhipicephalus sanguineus

文献类型： 外文期刊

第一作者： Wang, Qilin

作者： Wang, Qilin;Liu, Wenge;Wang, Yanlong;Chen, Zeyu;Liu, Guangyuan;Wang, Qilin;Li, Muxiao;Wang, Yanlong;Chen, Zeyu;Zhang, Zhenjie;Qi, Meng

作者机构：

关键词： Rhipicephalus sanguineus; MicroRNAs; Flotillin-1; Tick egg

期刊名称：VETERINARY RESEARCH COMMUNICATIONS （ 影响因子：2.0； 五年影响因子：2.1 ）

ISSN： 0165-7380

年卷期： 2025 年 49 卷 3 期

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收录情况： SCI

摘要： Identifying the microRNAs (miRNAs) that regulate the growth and development of Rhipicephalus sanguineus (Rh. sanguineus) is essential for developing effective control strategies against both the tick and tick-borne pathogens. This study reveals the antagonistic regulatory mechanism between miR-71* (the passenger strand of miRNA-71) and Flotillin-1 in the egg development of Rh. sanguineus. Through bioinformatics prediction and validation using a dual-luciferase reporter system, we demonstrate for the first time that miR-71* directly targets and regulates Flotillin-1. Functional experiments indicate that inhibiting miR-71* significantly increases tick egg weight, while suppressing Flotillin-1 reduces egg weight, thereby suggesting that these molecules negatively regulate egg developmental processes. This discovery provides a novel target for elucidating reproductive regulatory pathways in ticks and lays a theoretical foundation for developing control strategies against ticks and tick-borne pathogens.

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