Generation and efficacy evaluation of a recombinant adenovirus expressing the E2 protein of classical swine fever virus

文献类型： 外文期刊

第一作者： Sun, Yuan

作者： Sun, Yuan;Liu, Da-Fei;Wang, Yu-Fei;Liang, Bing-Bing;Cheng, Dan;Li, Na;Qi, Qiao-Fen;Zhu, Qing-Hu;Qiu, Hua-Ji

作者机构：

关键词： Infection;Methods and Techniques;Molecular Genetics: Biochemistry and Molecular Biophysics;Veterinary Medicine: Medical Sciences

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which causes significant economic losses to the pig industry worldwide. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. This study was aimed to develop a recombinant human adenovirus type 5 expressing the CSFV E2 gene (rAdV-E2) and evaluate its efficacy in rabbits and pigs. The results showed that the rabbits and the pigs immunized with the rAdV-E2 developed high-level CSFV-specific neutralizing antibodies. The rAdV-E2-immunized rabbits were protected from fever induced by infection with C-strain, which is pathogenic to the rabbit, and the rAdV-E2-immunized pigs were protected from lethal challenge with highly virulent Shimen strain. This indicates that the recombinant adenovirus can be an attractive candidate vaccine for preventing CSF.

分类号： S85

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