Putting CRISPR-Cas system in action: a golden window for efficient and precise genome editing for crop improvement

文献类型： 外文期刊

第一作者： Tariq, Arooj

作者： Tariq, Arooj;Yaqoob, Huwaida;Mushtaq, Muntazir;Bhat, Basharat Ahmad;Zargar, Sajad Majeed;Raza, Ali;Ali, Sajad;Charagh, Sidra;Mubarik, Muhammad Salman;Zaman, Qamar U.;Zaman, Qamar U.;Prasad, P. V. Vara;Mir, Rakeeb Ahmad;Mir, Rakeeb Ahmad;Zargar, Sajad Majeed;Raza, Ali

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关键词： breeding; CRISPR; Cas system; crop improvement; future crops; GE technologies; mutagenesis; wild crops

期刊名称：GM CROPS & FOOD-BIOTECHNOLOGY IN AGRICULTURE AND THE FOOD CHAIN （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2164-5698

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： The daunting task of feeding an ever-growing population is an immense challenge for the contemporary scientific community, especially in view of the rapidly changing climate throughout the world. Amidst these threatening crises, we witness rapid development in genome editing (GE) technologies, revolutionizing the field of applied genomics and molecular breeding. Various GE tools have been developed during the last two decades, but the CRISPR/Cas system has most recently made a significant impact on crop improvement. The major breakthroughs of this versatile toolbox are genomic modifications like single base-substitutions, multiplex GE, gene regulation, screening mutagenesis, and enhancing the breeding of wild crop plants. Previously, this toolbox was used to modify genes related to significant traits such as biotic/abiotic resistance/tolerance, post-harvest traits, nutritional regulation, and to address self-incompatibility analysis-related challenges. In the present review, we have demonstrated the functional dynamics of CRISPR-based GE and its applicability in targeting genes to accomplish novel editing of crops. The compiled knowledge will provide a solid foundation for highlighting the primary source for applying CRISPR/Cas as a toolbox for enhancing crops, to achieve food and nutritional security.

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