Effects of dietary supplementation with N-carbamylglutamate on maternal endometrium and fetal development during early pregnancy in Inner Mongolia white cashmere goats

文献类型： 外文期刊

第一作者： Zhang, Chong Zhi

作者： Zhang, Chong Zhi;Sang, Dan;Wu, Bao Sheng;Li, Sheng Li;Zhang, Chun Hua;Jin, Lu;Li, Jin Xia;Gu, Ying;Ga, Na Mei Ri;Sun, Hai Zhou;Hua, Mei

作者机构：

关键词： brown adipose tissue; fetal development; N-carbamylglutamate; pregnancy

期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.974； 五年影响因子：2.027 ）

ISSN： 1344-3941

年卷期： 2022 年 93 卷 1 期

页码：

收录情况： SCI

摘要： This study investigated the effects of dietary supplementation with N-carbamylglutamate (NCG) on maternal endometrium and fetal development during early pregnancy of Inner Mongolia white cashmere goats. Forty-eight pregnant Inner Mongolia white cashmere goats (average age 3 years old, average lactation parity 2, and average body weight 43.81 +/- 2.66 kg) were randomly allocated to three groups: a basal diet (control group, n = 16), a basal diet plus 0.30-g NCG/d (NCG1 group, n = 16), and a basal diet plus 0.40-g NCG/d (NCG2 group, n = 16). All of the does were housed in individual pens and the NCG treatment was conducted from Days 0 to 90 of pregnancy. At Days 17 and 90 of pregnancy, six representative pregnant does in each group were slaughtered. The current study results demonstrated that maternal NCG administration during early pregnancy effectively increased the arginine family of amino acids and the glucogenic amino acids concentrations and promoted the mRNA expression of osteopontin (OPN), alpha v and beta 3 integrins, and endometrial development of Inner Mongolia white cashmere goats. The supplementation improved the fetal brown adipose tissue (BAT) stores and the mRNA expression of UCP-1 and BMP7, thereby helping to the fetal early development.

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