Testosterone regulates thymic remodeling by altering metabolic reprogramming in male rats

文献类型： 外文期刊

第一作者： Li, Dong

作者： Li, Dong;Yao, Huan;Ren, Yonghao;Shang, Jiameng;Han, Xinfa;Cao, Xiaohan;Zeng, Xianyin;Song, Tianzeng;Song, Tianzeng;Zeng, Xianyin

作者机构：

关键词： Thymus; Testosterone; Glycolysis; Glutamate; Lipid metabolism; Tricarboxylic acid cycle

期刊名称：GENERAL AND COMPARATIVE ENDOCRINOLOGY （ 影响因子：2.7； 五年影响因子：2.6 ）

ISSN： 0016-6480

年卷期： 2024 年 348 卷

页码：

收录情况： SCI

摘要： The thymus is an energy-consuming organ, and its metabolism changes with atrophy. Testosterone regulates thymus remodeling (atrophy and regeneration). However, the characteristics of the energy metabolism during testosterone-mediated thymic atrophy and regeneration remain unclear. In this study, we demonstrated that testosterone ablation (implemented by immunocastration and surgical castration) induced global metabolic changes in the thymus. Kyoto Encyclopedia of Genes and Genomes pathway enrichment for differential metabolites and metabolite set enrichment analysis for total metabolites revealed that testosterone ablation affected thymic glycolysis, glutamate metabolism, and fatty acid beta-oxidation. Testosterone ablation-induced thymic regeneration was accompanied by attenuated glycolysis and glutamate metabolism and changed fatty acid composition and content. Testosterone supplementation in immunocastrated and surgically castrated rats enhanced glutaminolysis, reduced the level of unsaturated fatty acids, enhanced the beta-oxidation of unsaturated fatty acids in the mitochondria, boosted the tricarboxylic acid (TCA) cycle, and accelerated thymic atrophy. Overall, these results imply that metabolic reprogramming is directly related to thymic remodeling.

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