Toward the Heterologous Biosynthesis of Plant Natural Products: Gene Discovery and Characterization

文献类型： 外文期刊

第一作者： Guo, Hao

作者： Guo, Hao;Wang, Ning;Huo, Yi-Xin;Wang, Ning;Huo, Yi-Xin

作者机构：

关键词： plant natural products; synthetic biology; gene mining; microorganisms; candidate gene identification

期刊名称：ACS SYNTHETIC BIOLOGY （ 影响因子：5.249； 五年影响因子：5.373 ）

ISSN： 2161-5063

年卷期： 2021 年 10 卷 11 期

页码：

收录情况： SCI

摘要： Plant natural products (PNPs) represent a vast and diverse group of natural products, which have wide applications such as emulsifiers in cosmetics, sweeteners in foods, and active ingredients in medicines. Large-scale production of certain PNPs (e.g., artemisinin, taxol) has been implemented by reconstruction of biosynthetic pathways in heterologous hosts. However, unknown biosynthetic pathways greatly restrict wide applications of heterologous production of PNPs of interest. With the rapid development of sequencing and multiomics analysis technologies, huge amounts of omics data, i.e., genomics, transcriptomics, and proteomics, have been deposited in public databases, which is a precious resource for identification of the unknown biosynthetic pathway of PNPs. Herein, we have enumerated the approaches which have been widely used to screen candidate genes involved in the biosynthesis of PNPs of interest. We also discuss recent developments in the characterization of putative genes and elucidation of the complete biosynthetic pathway in heterologous hosts.

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