Whole-genome resequencing reveals the uniqueness of Subei yak

文献类型： 外文期刊

第一作者： Guo, Shaoke

作者： Guo, Shaoke;Wang, Xingdong;Guo, Xian;Guo, Shaoke;Wang, Xingdong;Guo, Xian;Yu, Tianjun;Zhao, Shuangquan;Zhao, Erjun;Ba, Teer;Gan, Manyu;Dong, Cunmei;Yin, Lian;Ke, Xikou;Dana, Dawuti

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关键词： population structure; SNP; Subei yak; whole-genome resequencing

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 0021-8812

年卷期： 2024 年 102 卷

页码：

收录情况： SCI

摘要： Subei yak is an essential local yak in the Gansu Province, which genetic resource has recently been discovered. It is a meat-milk dual-purpose variety with high fecundity and relatively stable population genetic structure. However, its population genetic structure and genetic diversity are yet to be reported. Therefore, this study aimed to identify molecular markers of Subei yak genome by whole-genome resequencing, and to analyze the population structure and genetic diversity of Subei yak. This study screened 12,079,496 single nucleotide polymorphism (SNP) molecular markers in the 20 Subei yaks genome using whole-genome resequencing technology. Of these SNPs, 32.09% were located in the intronic region of the genome. Principal component analysis, phylogenetic analysis, and population structure analysis revealed that the Subei yak belonged to an independent group in the domestic yak population. A selective clearance analysis was carried out on Subei yak and other domestic yaks, and the genes under positive selection were annotated. The functional enrichment analysis showed that Subei yak possessed prominent selection characteristics in terms of external environment perception, hypoxia adaptation, and muscle development. Furthermore, Subei yak showed excellent muscle fat deposition and meat quality traits. Thus, this study will serve as a reference for discovering population structure, genetic evolution, and other unique traits of Subei yak and for expanding the genetic variation catalog of yaks. The whole-genome resequencing data analysis showed that the Subei yak belonged to an independent group in the domestic yak population. Subei yak is an important local yak genetic resource newly discovered in Gansu Province. In this study, the molecular markers of Subei yak genome were identified by whole-genome resequencing. Principal component analysis, phylogenetic analysis, and population structure analysis showed that Subei yak belonged to an independent group in the domestic yak population. In addition, functional enrichment analysis showed that Subei yaks had prominent selection characteristics in external environment perception, hypoxia adaptation, and muscle development.

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