A novelty strategy for the fast analysis of sulfonamide antibiotics in fish tissue using magnetic separation with high-performance liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Li, Jincheng

作者： Li, Jincheng;Liu, Huan;Zhang, Jing;Wu, Lidong;Liu, Yang

作者机构：

关键词： sulfonamide antibiotics; magnetic separation; HPLC-MS; MS; fish tissue

期刊名称：BIOMEDICAL CHROMATOGRAPHY （ 影响因子：1.902； 五年影响因子：1.809 ）

ISSN： 0269-3879

年卷期： 2016 年 30 卷 8 期

页码：

收录情况： SCI

摘要： A simple, fast and low-cost extraction method with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) determination was developed on sulfonamide antibiotics (SAs) in fish tissue. Magnetic separation was first introduced into the rapid sample preparation procedure combined with acetonitrile extraction for the analysis of SAs. Partitioning was rapidly achieved between acetonitrile solution and solid matrix by applying an external magnetic field. Acetonitrile solution was collected and concentrated under a nitrogen stream. The residue was redissolved with 1 parts per thousand formic acid aqueous solution and defatted with n-hexane before analysis. The recoveries of SAs were in the range of 74.87-104.74%, with relative standard deviations <13%. The limits of quantification and the limits of detection for SAs ranged from 5.0 to 25.0g (kg-1) and from 2.5 to 10.0g (kg-1), respectively. The presented extraction method proved to be a rapid method which only took 20min for one sample preparation procedure. Copyright (c) 2016 John Wiley & Sons, Ltd.

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