Transcriptional response of four C1q domain containing protein (C1qDC) genes from Venerupis philippinarum exposed to the water soluble fraction of No.0 diesel oil

文献类型： 外文期刊

第一作者： Zhang, Linbao

作者： Zhang, Linbao;Sun, Wei;Cai, Wengui;Zhang, Zhe;Chen, Haigang;Ma, Shengwei;Jia, Xiaoping;Zhang, Linbao;Sun, Wei;Cai, Wengui;Zhang, Zhe;Chen, Haigang;Ma, Shengwei;Jia, Xiaoping

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关键词： C1q-domain-containing protein (C1qDC); mRNA expression; Venerupis philippinarum; Water soluble fraction of No.0 diesel oil (WSFD)

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2016 年 132 卷

页码：

收录情况： SCI

摘要： As pattern recognitionreceptors, the C1q-domain-containing (C1qDC) proteins play an important role in the pathogen recognition and complement pathway activation. In the present study, four novel C1q domain containing proteins (designated as VpC1qDC1,VpC1qDC2,VpC1qDC3 and VpC1qDC4) were cloned and characterized from clam Venerupis philippinarum. The four VpC1qDCs all possessed the conserved features critical for the fundamental structure and function of the C1q family. The four VpC1qDCs genes showed differential response profiles after exposure to the water soluble fraction of No.0 diesel oil (WSFD). More notably, VpC1qDC1 and VpC1qDC3 were more sensitive to low concentration of WSFD, as their mRNA level changed by higher magnitudes. In addition, VpC1qDC2 and VpC1qDC4 displayed notable increases with larger amplitude to high concentration of WSFD. All these results suggested that the transcriptional response of VpC1qDCs genes were probably a protective mechanism of the cell to oils pollution. The diverse expression patterns of VpC1qDCs demonstrated that VpC1qDC1 and VpC1qDC3 were sensitive responders to environmental stress in V. philippinarum. (C) 2016 Elsevier Inc. All rights reserved.

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