Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health

文献类型： 外文期刊

第一作者： Li, Ting

作者： Li, Ting;Wang, Zhenlong;Wang, Jinquan;Han, Bing;Tao, Hui;Liu, Jie;Wang, Xiumin;Li, Ting;Wang, Zhenlong;Wang, Jinquan;Han, Bing;Tao, Hui;Liu, Jie;Wang, Xiumin;Li, Ting;Guo, Jianhua;de la Fuente-Nunez, Cesar;de la Fuente-Nunez, Cesar;de la Fuente-Nunez, Cesar;de la Fuente-Nunez, Cesar;de la Fuente-Nunez, Cesar

作者机构：

关键词： Bacterial resistance; Antibiotics; Mechanism of action; Antimicrobial peptides; Strategies; Global health

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 860 卷

页码：

收录情况： SCI

摘要： The spread of bacterial drug resistance has posed a severe threat to public health globally. Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbalmedicines, conventional antibiotics, and antimicrobial peptides. We summarize the influence of bacterial drug resistance on global health and its economic burden while highlighting the resistance mechanisms developed by bacteria. Based on the One Health concept, we propose 4A strategies to combat bacterial resistance, including prudent Application of antibacterial agents, Administration, Assays, and Alternatives to antibiotics. Finally, we identify several opportunities and unsolved questions warranting future exploration for combating bacterial resistance, such as predicting genetic bacterial resistance through the use of more effective techniques, surveying both genetic determinants of bacterial resistance and the transmission dynamics of antibiotic resistance genes (ARGs).

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