Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro

文献类型： 外文期刊

第一作者： Gong, Mei-jiao

作者： Gong, Mei-jiao;Wang, Wen-hui;Gong, Mei-jiao;Li, Shi-fang;Xie, Yin-li;Zhao, Fu-rong;Shao, Jun-jun;Zhang, Yong-guang;Chang, Hui-yun

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关键词： antiviral; FMDV; homoharringtonine; RNA virus; viral replication

期刊名称：JOURNAL OF MEDICAL VIROLOGY （ 影响因子：2.327； 五年影响因子：2.075 ）

ISSN： 0146-6615

年卷期： 2019 年 91 卷 9 期

页码：

收录情况： SCI

摘要： Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoof animals including cattle, swine, sheep, goats, and lots of wild species. Effectively control measures are urged needed. Here, we showed that homoharringtonine treatment exhibited a strong inhibitory effect against two different strains of FMDVs (O/MYA98/BY/2010 and A/GD/MM/2013) in swine kidney (IBRS-2) cells. Further experiments demonstrated that homoharringtonine did not affect virus attachment or entry. Using time-of-addition assays, we found that the antiviral activity of homoharringtonine occurred primarily during the early stage of infection. These results demonstrated that homoharringtonine might be an effective anti-FMDV drug. Further studies are required to explore the antiviral activity of homoharringtonine against FMDV replication in vivo.

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