Basal Level p53 Suppresses Antiviral Immunity Against Foot-And-Mouth Disease Virus

文献类型： 外文期刊

第一作者： Zhang, Tianliang

作者： Zhang, Tianliang;Yao, Kaishen;Wu, Run;Zhang, Tianliang;Chen, Haotai;Liu, Xinsheng;Qi, Linlin;Gao, Xin;Wang, Kailing;Yao, Kaishen;Zhang, Jie;Sun, Yuefeng;Zhang, Yongguang;Chen, Haotai;Liu, Xinsheng;Qi, Linlin;Zhang, Jie;Sun, Yuefeng;Zhang, Yongguang

作者机构：

关键词： p53; MDM2; foot-and-mouth disease virus; innate immunity; interferon

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN：

年卷期： 2019 年 11 卷 8 期

页码：

收录情况： SCI

摘要： Tumor suppressor protein p53 (p53) is a master transcription factor that plays key roles in cell cycle arrest, apoptosis, senescence, and metabolism, as well as regulation of innate immunity during virus infection. In order to facilitate their replication and spreading, viruses have evolved to manipulate p53 function through different strategies, with some requiring active p53 while others demand reduction/inhibition of p53 activity. However, there are no clear-cut reports about the roles of p53 during the infection of foot-and-mouth disease virus (FMDV), the causative agent of a highly contagious foot-and-mouth disease (FMD) of cloven-hoofed animals. Here we showed that p53 level was dynamically regulated during FMDV infection, being degraded at the early infection stage but recovered to the basal level at the late stage. Cells depleted of p53 showed inhibited FMDV replication and enhanced expression of the immune-related genes, whereas overexpression of p53 didn't affect the viral replication. Viral challenge assay with p53 knockout mice obtained similar results, with viral load decreased, histopathological changes alleviated, and lifespan extended in the p53 knockout mice. Together, these data demonstrate that basal level p53 is required for efficient FMDV replication by suppressing the innate immunity.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序