Evolutionary history of Simbu serogroup orthobunyaviruses in the Australian episystem

文献类型： 外文期刊

第一作者： Wang, Jidong

作者： Wang, Jidong;Yin, Hong;Wang, Jidong;Amos-Ritchie, Rachel;Blasdell, Kim R.;Firth, Cadhla;Davis, Steven S.;Holmes, Edward C.;Holmes, Edward C.;Walker, Peter J.

作者机构：

关键词： Orthobunyavirus; Simbu serogroup; Segment reassortment; Phylogenetics

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2019 年 535 卷

页码：

收录情况： SCI

摘要： Orthobunyaviruses of the Simbu serogroup are transmitted by insects (primarily biting midges) and infect mammals and/or birds. Many have been associated with disease in livestock or humans. The orthobunyavirus genome comprises three negative-sense RNA segments (L, M and S). We report the complete coding sequences of 57 isolates of Simbu serogroup viruses collected in Australia during 1968-1984. Phylogenetic analysis identified novel genogroups of Akabane virus (AKAV), Aino virus (AINOV) and Peaton virus, and provided evidence of constrained movement of AKAV between epidemiological systems in the northern and eastern regions of the continent. Differential clustering of AKAV isolates in trees inferred from L, M and S segments was indicative of intratypic segment reassortment. Similarly, intertypic segment reassortment was detected between AKAV and Tinaroo virus, and between AINOV and Douglas virus. L segments representing novel genogroups were detected in AINOV reassortants, suggesting the presence of unidentified Simbu group viruses in the episystem.

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