Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone

文献类型： 外文期刊

第一作者： Ke, Shaoyong

作者： Ke, Shaoyong;Zhang, Zhigang;Liu, Manli;Fang, Wei;Huang, Daye;Wan, Zhongyi;Zhou, Ronghua;Wang, Kaimei;Shi, Liqiao

作者机构：

关键词： Epiandrosterone; androsterone; isatin; conjugate; synthesis; cytotoxic activity

期刊名称：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY （ 影响因子：5.051； 五年影响因子：4.598 ）

ISSN： 1475-6366

年卷期： 2019 年 34 卷 1 期

页码：

收录情况： SCI

摘要： Steroids are classes of natural products widely distributed in nature, which have been demonstrated to exhibit broad biological functions, and have also attracted increasing interest from bioorganic and pharmaceutical researches. In order to develop novel chemical entities as potential cytotoxic agents, a series of steroidal isatin conjugations derived from epiandrosterone and androsterone were efficiently prepared and characterized, and all these obtained compounds were screened for their potential cytotoxic activities. The preliminary bioassay indicated that most of the newly synthesized compounds exhibited good cytotoxic activities against human gastric cancer (SGC-7901), melanoma (A875), and hepatocellular liver carcinoma (HepG2) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising scaffold for further development of potential anticancer agents.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序