Phloroglucinol heterodimers and bis-indolyl alkaloids from the sponge-derived fungus Aspergillus sp. SCSIO 41018

文献类型： 外文期刊

第一作者： Guo, Cui

作者： Guo, Cui;Lin, Xiuping;Salendra, Limbadri;Liao, Shengrong;Yang, Bin;Zhou, Xuefeng;Wang, Junfeng;Liu, Yonghong;Guo, Cui;Salendra, Limbadri;Liu, Yonghong;Wang, Pei;Kong, Fandong;Liu, Yonghong

作者机构：

期刊名称：ORGANIC CHEMISTRY FRONTIERS （ 影响因子：5.281； 五年影响因子：4.89 ）

ISSN： 2052-4129

年卷期： 2019 年 6 卷 17 期

页码：

收录情况： SCI

摘要： Gilluones A-C (1-3), three new phloroglucinol heterodimers, asterriquinones I-K (4-6), three new bis-indolylquinones, and asterriquinols G-I (7-9), three new bis-indolylbenzenoids, were isolated from the sponge-derived fungus Aspergillus sp. SCSIO 41018 together with five known bis-indolyl alkaloids (10-14). Their structures were determined by detailed spectroscopic analyses, X-ray diffraction, a modified Mosher's method and electronic circular dichroism analysis. Gilluone A (1) possessed an unprecedented heterodimer polyketide skeleton fused by intermolecular [4 + 2] Diels-Alder cycloaddition featuring a novel cage structure bearing ketal and hemiketal functionalities. Gilluone B (2) possessed a heterodimer acyl phloroglucinol featuring amino and ester groups. Compared with previous bis-indolylquinones, asterriquinone I (5) represented the first reported bis-indolylquinone possessing a chlorine atom. Asterriquinones I-K (4-6) displayed cytotoxic activities against K562, BEL-7042, SGC-7901, A549, and HeLa cell lines. A possible biosynthetic pathway for gilluones A-C (1-3) was proposed.

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