Ubiquitin Proteins and the Orchestration of Transcription Factors Activity

文献类型： 外文期刊

第一作者： He, Yuqi

作者： He, Yuqi;Zhang, Kaixuan;Zhou, Meiliang;Georgiev, Milen, I;Georgiev, Milen, I

作者机构：

关键词： E3 ligase; phytohormone signaling; plants; protein degradation; transcription factor

期刊名称：CRITICAL REVIEWS IN PLANT SCIENCES （ 影响因子：5.188； 五年影响因子：9.148 ）

ISSN： 0735-2689

年卷期： 2021 年 40 卷 4 期

页码：

收录情况： SCI

摘要： The ubiquitin proteasome system is a key pathway, regulating targeted proteins degradation. A critical step is regulated by E3 ubiquitin ligases, which facilitates the transfer of ubiquitin moieties to substrate proteins, leading proteins degradation via 26S proteasome. However, the number of known ubiquitin dependent processes is still relatively small. Since some stress-related transcription factors are usually essential under stress conditions, while playing negative roles during normal growth, hence their protein levels need to be precisely regulated. However, the mechanism of ubiquitin pathway, regulating transcription factors stability has not been yet summarized. In this review, we attempted to outline the mechanism of E3 ligases dependent transcription factors degradation and discuss the comprehensive role of E3 ligases in phytohormone signaling.

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