文献类型： 外文期刊
第一作者： Liu, Chao
作者： Liu, Chao;Zhou, Hou-ning;Zhang, Rui-rui;Wang, Xin-kun;Guo, Xu;Wang, Qing;Sun, Jin-yue;He, Sheng-wen;Zhang, Jin-bao
作者机构：
关键词： Geniposide; Hyperuricemia; Renal dysfunction; Renal inflammation; Nephroprotective effects
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2019 年 61 卷
页码：
收录情况： SCI
摘要： Hyperuricemia is a key risk factor for kidney disease. Geniposide possesses various pharmacological activities, however, to our knowledge, no previous work investigated the therapeutic effect of geniposide on urate nephropathy. The present study established a chronic hyperuricemia model using a combination of adenine and ethambutol administration. The potential beneficial effects and mechanisms of geniposide on hyperuricemia and nephropathy were also investigated. The results demonstrated that geniposide significantly decreased SUA levels via inhibition of the XOD activity and increasing the excretion of urinary uric acid. Geniposide also markedly improved kidney damage related to hyperuricemia. Further investigation indicated that geniposide improved the symptoms of nephropathy via decreasing the production of proinflammatory cytokines, including IL-1 beta, PG-E-2, and TNF-alpha, and inhibiting the expression of TGF-1 beta. The molecular mechanism of action may be associated with suppression of TLR4/MyD88 signaling and NLRP3 inflammasome activation to reduce IL-1 beta and TNF-alpha production respectively in hyperuricemic mice.
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