Ginkgolide B and bilobalide promote the growth and increase beta-catenin expression in hair follicle dermal papilla cells of American minks

文献类型： 外文期刊

第一作者： Zhang, Haihua

作者： Zhang, Haihua;Shi, Qiumei;Wang, Yaqi;Zhang, Haihua;Wang, Shiyong;Yang, Fuhe;Li, Guangyu;Nan, Weixiao

作者机构：

关键词： bilobalide; dermal papilla; ginkgolide B; hair follicle; beta-catenin

期刊名称：BIOFACTORS （ 影响因子：6.113； 五年影响因子：5.365 ）

ISSN： 0951-6433

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收录情况： SCI

摘要： The regeneration of proliferation potential of dermal papilla (DP) cells contributes to the treatment of hair loss disorders. Ginkgolide B (GKB) and bilobalide (BB) are two functional components isolated from Ginkgo biloba that can promote hair growth. In the current study, the effect of GKB or BB on DP cell viability and the related signaling was assessed. Hair follicles were isolated from minks, and the growth of hair follicles was measured under the administration of GKB or BB. DP cells isolated from minks were also subjected to GKB or BB. The administration of GKB or BB induced the growth of hair follicles. The viability of DP cells was also increased by GKB or BB as illustrated by methyl thiazolyl tetrazolium and flow cytometry detection. Moreover, the secretion of VEGF was enhanced by GKB or BB. At molecular level, the activities of Akt, ERK1/2, and beta-catenin were induced by GKB, whereas BB only increased the activities of Akt and beta-catenin. In conclusion, although the two components influenced the beta-catenin signaling activity in distinct mechanisms, they both increased the viability of DP cells and promoted the cycle of hair follicles.

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