Antiviral effect of amiloride on replication of foot and mouth disease virus in cell culture

文献类型： 外文期刊

第一作者： Gong, Mei-jiao

作者： Gong, Mei-jiao;Chang, Yan-yan;Shao, Jun-jun;Li, Shi-fang;Zhang, Yong-guang;Chang, Hui-yun

作者机构：

关键词： FMDV; Antiviral activity; Amiloride; In vitro

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2019 年 135 卷

页码：

收录情况： SCI

摘要： Recently, amiloride was shown to potently suppress Coxsackievirus B3 (CVB3) replication. In the current study, we investigated whether amiloride could also exhibit antiviral activity against foot-and-mouth disease virus (FMDV), which belongs to the same family (Picornaviridae) as CVB3. We found that amiloride exerted antiviral activity in a dose-dependent manner against two strains of FMDV in IBRS-2 cells, with slight cytotoxicity at 1000 mu M. Besides, amiloride did not inhibit the attachment and entry of FMDV in IBRS-2 cells, but prevented early viral replication. These data implied that amiloride could be a promising candidate for further research as a potential antiviral drug against FMDV infection.

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