Genome-wide association studies for the number of animals born alive and dead in duroc pigs

文献类型： 外文期刊

第一作者： Chen, Zitao

作者： Chen, Zitao;Ye, Shaopan;Teng, Jinyan;Diao, Shuqi;Yuan, Xiaolong;Chen, Zanmou;Zhang, Hao;Li, Jiaqi;Zhang, Zhe

作者机构：

关键词： Duroc; Pig; GWAS; Reproductive traits; Mortality

期刊名称：THERIOGENOLOGY （ 影响因子：2.74； 五年影响因子：2.93 ）

ISSN： 0093-691X

年卷期： 2019 年 139 卷

页码：

收录情况： SCI

摘要： Litter size is one of the most important economic traits for pig production as it is directly related to the production efficiency. As an important litter size trait in pigs, the number of piglets born alive at birth (NBA) receives widespread interests in the pig industry. However, traits of piglets born dead, including the number of stillborn piglets (NS) and the piglets mummified at birth (NM) should be noted to explain the loss of reproduction. Herein, in the present study, a total of 803 producing sows were sampled and 2807 farrowing records for NBA, NM, and NS traits were collected in a Duroc swine population. Subsequently, a genome-wide association study (GWAS) was performed for NBA, NS and NM in parity groups 1 to 5. In total, 10 putative regions were found associated with these traits. After stepwise conditional analyses around the putative regions, eight independent signals were ultimately identified for NBA, NS, and NM, and there were seven promising candidate genes related to these traits, including ARIDIA, RXRG, NFATC4, ABTB2, GRAMD1B, NDRG1, and APC. Our findings contribute to the understanding of the significant genetic causes of piglets born alive and dead, and could have a positive effect on pig production efficiency and economic profits. (C) 2019 Elsevier Inc. All rights reserved.

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