Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L.

文献类型： 外文期刊

第一作者： Sheng, Cheng-Wang

作者： Sheng, Cheng-Wang;Huang, Qiu-Tang;Jiang, Jie;Jia, Zhong-Qiang;Han, Zhao-Jun;Zhao, Chun-Qing;Liu, Gen-Yan;Ren, Xue-Xiang

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关键词： fluralaner; GABA receptor; honeybee; isoxazoline; insecticide

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：4.845； 五年影响因子：4.674 ）

ISSN： 1526-498X

年卷期： 2019 年 75 卷 11 期

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收录情况： SCI

摘要： BACKGROUND Fluralaner, a novel pesticide that targets the gamma-aminobutyric acid (GABA) receptor (GABAR) subunit of resistant to dieldrin (RDL), exhibits strong potential to be an insecticide to control agricultural insect pests. However, the risk and action of fluralaner to economic insects, e.g., honeybee Apis mellifera Linnaeus, remains unclear. RESULTS In this study, both oral and contact toxicity of fluralaner to honeybee were found to be 0.13 mu g adult(-1). Abamectin, dieldrin, ethiprole, alpha-endosulfan, fipronil and fluralaner strongly inhibited the GABA-induced current in A. mellifera RDL (AmRDL), expressed in Xenopus laevis oocytes, with median inhibitory concentration (IC50) values of 7.99, 868.1, 27.10, 412.0, 11.21 and 13.59 nM, respectively. The binding free energy and electrophysiological response of AmRDL and insecticides were opposite. The correlation values between toxicity (to A. mellifera) and binding free energy/electrophysiological inhibition (to AmRDL) were at a moderate level. CONCLUSION In conclusion, we report for the first time the notable risk of fluralaner to honeybee in vivo and compared the actions of GABAR-targeted insecticides on the AmRDL receptor. (c) 2019 Society of Chemical Industry

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