Antiviral activity of merimepodib against foot and mouth disease virus in vitro and in vivo

文献类型： 外文期刊

第一作者： Li, Shi-fang

作者： Li, Shi-fang;Gong, Mei-jiao;Shao, Jun-jun;Sun, Yue-feng;Zhang, Yong-guang;Chang, Hui-yun

作者机构：

关键词： FMDV; Merimepodib; Antiviral activity; In vivo

期刊名称：MOLECULAR IMMUNOLOGY （ 影响因子：4.407； 五年影响因子：4.227 ）

ISSN： 0161-5890

年卷期： 2019 年 114 卷

页码：

收录情况： SCI

摘要： Foot and mouth disease virus (FMDV), a member of family Picornviridae, belongs to the genus Aphthovirus, which causes foot and mouth disease (FMD), a highly transmissible disease that affects cloven-hoof animals. In spite of the fact that efficient vaccines are available, effective antiviral molecules for FMD are needed to reduce viral infection during early stages of infection. In this study, merimepodib was found to efficiently inhibit FMDV replication in a dose-dependent manner. The 50% inhibitory concentration (IC50) of merimepodib antiviral activity against two distinct FMDV strains (O/MYA98/BY/2010 and A/GD/MM/CHA/2013) was estimated to be 7.859 and 2.876 mu M, respectively, while the 50% cytotoxic concentration (CC50) of merimepodib was found to be 47.74 mu M. Furthermore, treatment with 30 mu g merimepodib efficiently prolonged the survival time of suckling mice infected with FMDV. Taken together, these results suggested that merimepodib has the potential to be a novel antiviral agent against FMDV.

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