Effect of the total replacement of fishmeal with plant proteins and supplemental essential amino acids in the extruded diet on antioxidants genes, enzyme activities, and immune response in juvenile blunt snout bream

文献类型： 外文期刊

第一作者： Mokrani, Ahmed

作者： Mokrani, Ahmed;Ren, Mingchun;Liang, Hualiang;Yang, Qiang;Ji, Ke;Kasiya, Hopeson Chisomo;Ge, Xianping;Ren, Mingchun;Ge, Xianping

作者机构：

关键词： Blunt snout bream; Fish meal reduction; Essential amino acids supplementation; Antioxidants; Enzyme activity; Immune responses

期刊名称：AQUACULTURE INTERNATIONAL （ 影响因子：2.235； 五年影响因子：2.616 ）

ISSN： 0967-6120

年卷期： 2020 年 28 卷 2 期

页码：

收录情况： SCI

摘要： Four diets were formulated with or without fishmeal (FM) and essential amino acid (EAA) supplementation fed to the blunt snout bream throughout 8 weeks. The results showed that total cholesterol level (TC) was decreased significantly against FM reduction (P < 0.05). Aspartate aminotransferase (AST), alanine transaminases (ALT), and alkaline phosphatase (ALP) activities were affected neither by FM reduction nor EAA supplementation (P > 0.05). Catalase (CAT) activity and glutathione (GSH) content were significantly augmented and diminished in the group fed diet 3 respectively (P < 0.05). Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content did not alter either by FM reduction or EAA supplementation (P > 0.05). Glutathione peroxidase (GPx) activity was elevated significantly either by reducing FM or supplementing EAA (P < 0.05). The relative expression of nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like-ECH-associated protein 1 (Keap1), and GPx was significantly augmented (P < 0.05) in the EAA-supplemented groups. Neither FM reduction nor EAA supplementation altered the relative expression of SOD (P > 0.05), whereas the relative expression of copper-zinc superoxide dismutase (Cu/Zn-SOD) decreased against FM reduction (P < 0.05). The relative expressions of Interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha), interleukin 10 (IL10), and nuclear factor-kappa B (NF-kappa B) were diminished significantly in FM-reduced groups (P < 0.05). The supplementation of EAA significantly increased the relative expression of signal transducer and activator of transcription 4 (STAT4) (P < 0.05). In conclusion, the results revealed that dietary plant proteins with EAA supplementation significantly affected the physiological status and immune responses in blunt snout bream.

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