Degradation of Aflatoxin B-1 and Zearalenone by Bacterial and Fungal Laccases in Presence of Structurally Defined Chemicals and Complex Natural Mediators

文献类型： 外文期刊

第一作者： Wang, Xiaolu

作者： Wang, Xiaolu;Bai, Yingguo;Huang, Huoqing;Tu, Tao;Wang, Yuan;Wang, Yaru;Luo, Huiying;Yao, Bin;Su, Xiaoyun

作者机构：

关键词： laccase; mycotoxins; aflatoxin B-1; zearalenone; mediator; detoxification

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

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年卷期： 2019 年 11 卷 10 期

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收录情况： SCI

摘要： Aflatoxin B-1 (AFB(1)) and zearalenone (ZEN) exert deleterious effects to human and animal health. In this study, the ability of a CotA laccase from Bacillus subtilis (BsCotA) to degrade these two mycotoxins was first investigated. Among the nine structurally defined chemical compounds, methyl syringate was the most efficient mediator assisting BsCotA to degrade AFB(1) (98.0%) and ZEN (100.0%). BsCotA could also use plant extracts, including the Epimedium brevicornu, Cucumis sativus L., Lavandula angustifolia, and Schizonepeta tenuifolia extracts to degrade AFB(1) and ZEN. Using hydra and BLYES as indicators, it was demonstrated that the degraded products of AFB(1) and ZEN using the laccase/mediator systems were detoxified. Finally, a laccase of fungal origin was also able to degrade AFB(1) and ZEN in the presence of the discovered mediators. The findings shed light on the possibility of using laccases and a mediator, particularly a natural plant-derived complex mediator, to simultaneously degrade AFB(1) and ZEN contaminants in food and feed.

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