文献类型： 外文期刊
第一作者： Li, Jiaqi
作者： Li, Jiaqi
作者机构：
关键词： Duroc; pig; GWAS; reproductive traits
期刊名称：ANIMALS （ 影响因子：2.752； 五年影响因子：2.942 ）
ISSN： 2076-2615
年卷期： 2019 年 9 卷 10 期
页码：
收录情况： SCI
摘要： Simple Summary Reproductive traits are economically important in the pig industry, and it is critical to explore their underlying genetic architecture. Hence, four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. Through a genome-wide association study in a Duroc pig herd, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. These findings help to understand the genetic basis of porcine reproductive traits and could be applied in pig breeding programs. Abstract In the pig industry, reproductive traits constantly influence the production efficiency. To identify markers and candidate genes underlying porcine reproductive traits, a genome-wide association study (GWAS) was performed in a Duroc pig population. In total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, and four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. The results showed that 20 potential SNPs reached the level of suggestive significance and were associated with these traits of interest. Several important candidate genes, including TXN2, KCNA1, ENSSSCG00000003546, ZDHHC18, MAP2K6, BICC1, FAM135B, EPHB2, SEMA4D, ST3GAL1, KCTD3, FAM110A, TMEM132D, TBX3, and FAM110A, were identified and might compose the underlying genetic architecture of porcine reproductive traits. These findings help to understand the genetic basis of porcine reproductive traits and provide important information for molecular breeding in pigs.
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