Pharmacokinetics and tissue distribution of bronopol in grass carp, Ctenopharyngodon Idella, at 15 and 20 degrees C

文献类型： 外文期刊

第一作者： Ma, Rongrong

作者： Ma, Rongrong;Zhan, Jia;Fang, Wenhong;Yang, Xianle;Hu, Kun

作者机构：

关键词： bronopol; different temperatures; grass carp; pharmacokinetics; tissue distribution

期刊名称：AQUACULTURE RESEARCH （ 影响因子：2.082； 五年影响因子：2.415 ）

ISSN： 1355-557X

年卷期： 2020 年 51 卷 2 期

页码：

收录情况： SCI

摘要： This study explored the pharmacokinetic characteristics of bronopol in grass carp (Ctenopharyngodon idella) under different temperatures. The concentrations of bronopol in the plasma and tissues (kidney, liver and muscle) of grass carp after soaking in bronopol (6.75 mu g/ml) at 15 and 20 degrees C were determined using liquid chromatography-mass spectrometry. The concentrations of bronopol in both plasma and tissue first increased and then decreased with soaking time at both tested temperatures. The peak bronopol concentrations at 15 degrees C (plasma: 8.934 mu g/ml; kidney: 9.23 mu g/g; liver: 9.47 mu g/g; and muscle: 7.98 mu g/g) were slightly lower than those at 20 degrees C (plasma: 9.654 mu g/ml; kidney: 10.83 mu g/g; liver: 13.40 mu g/g; and muscle: 8.68 mu g/g). In an analysis of pharmacokinetic parameters, the bronopol concentration-time profiles for plasma were best described by a two-compartment, open pharmacokinetic model with first-order absorption. The t(1/2 beta) for plasma at 15 and 20 degrees C was 82.933 and 92.041 hr, respectively, indicating that the elimination of bronopol was faster at 15 degrees C than at 20 degrees C. In addition, AUC(0-t) and AUC(0-infinity) values of bronopol were 477.892 and 495.809 mu g/L hr at 15 degrees C and 495.809 and 589.859 mu g/L hr at 20 degrees C, indicating that the content of bronopol in the organism was higher at higher temperature.

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