Antibacterial stilbenes from the tubers of Bletilla striata

文献类型： 外文期刊

第一作者： Jiang, Sai

作者： Jiang, Sai;Chen, Chang-Fen;Ma, Xiao-Pan;Zhang, Ni;Pan, Wei-Dong;Jiang, Sai;Wang, Meng-Yun;Wang, Wei;Zhang, Ni;Pan, Wei-Dong;Zhang, Ni;Pan, Wei-Dong;Wu, Ming-Kai;Xia, Yu

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关键词： Bletilla striata; Stilbenoids; Bibenzyls; Phenanthrenes; Antibacterial activities

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2019 年 138 卷

页码：

收录情况： SCI

摘要： Three new bibenzyl derivatives (bletstrins A-C, 1 3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilln striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 mu g/mL) against S. aureus ATCC 6538.

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