Microscopic hollow hydrogel springs, necklaces and ladders: a tubular robot as a potential vascular scavenger

文献类型： 外文期刊

第一作者： Liang, Shumin

作者： Liang, Shumin;Tu, Yaqing;Chen, Qing;Zhang, Lidong;Jia, Wei;Wang, Wenhan;Jia, Wei;Wang, Wenhan

作者机构：

期刊名称：MATERIALS HORIZONS （ 影响因子：13.266； 五年影响因子：14.931 ）

ISSN： 2051-6347

年卷期： 2019 年 6 卷 10 期

页码：

收录情况： SCI

摘要： Microscopic hollow hydrogel fibers are capable of being used as carriers, scaffolds and actuators for biomedical applications. However, preparation of sophisticated geometries remains a challenge. We herein present a non-coaxial microfluidic method, which is different from traditional coaxial devices that form perfusable channels during the extruding process. Our method produces solid microfibers into tris(hydroxymethy)aminomethane-HCl buffered solution containing CuSO4 and H2O2 elements, where chemical reactions contribute to hollow structures. The process doesn't require coaxial nozzles, whereby it allows generation of sophisticated geometries with interconnected channels including single- and double-helical springs, necklaces and ladders by adjusting the distance between the nozzles and liquid level. After magnetizing the hollow microfibers, they can be steered by magnetic actuation to generate controllable movements and to navigate across unstructured environments in liquid systems. The hollow microfibers are non-toxic. We thus show an interesting concept by preparing hollow microfibers into a tubular small-scale robot that can shift inside an artificial blood vessel to clean up blockages, demonstrating potential application as a vascular scavenger.

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