Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities
文献类型： 外文期刊
第一作者： Guo Jiaocen
作者： Guo Jiaocen;Ding Qiong;Wu Yougen;Guo Jiaocen;Ma Qingyun;Kong Fangdong;Xie Qingyi;Zhou Liman;Zhao Youxing
作者机构：
关键词： Ganoderma ahmadii Steyaret; meroterpenoid compound; PTP1B inhibitory effect
期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：1.652； 五年影响因子：1.2 ）
ISSN： 0253-2786
年卷期： 2019 年 39 卷 11 期
页码：
收录情况： SCI
摘要： Three new meroterpenoids of ganoduriporols C similar to E were isolated from the fruiting bodies of Ganoderma ahmadii Steyaret by silica gel column, high performance liquid chromatography (HPLC) and other chromatography methods. Their structures were determined by spectroscopic techniques including NMR and HR-ESI-MS. Their inhibitory activities for protein tyrosine phosphatase 1B (PTP1B) in vitro were tested. The results showed that the three compounds had obvious PTP1B inhibitory activitiy with the IC50 values of 19.1, 17.81, and 29.6 mu mol.L-1, respectively.
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