Lipidomes in health and disease: Analytical strategies and considerations

文献类型： 外文期刊

第一作者： Wei, Fang

作者： Wei, Fang;Oresic, Matej;Lamichhane, Santosh;Oresic, Matej;Lamichhane, Santosh;Oresic, Matej;Oresic, Matej;Hyotylainen, Tuulia

作者机构：

关键词： Biomarkers; Lipid identification; Lipidomics; Mass spectrometry; Metabolomics; Quantification

期刊名称：TRAC-TRENDS IN ANALYTICAL CHEMISTRY （ 影响因子：12.296； 五年影响因子：11.446 ）

ISSN： 0165-9936

年卷期： 2019 年 120 卷

页码：

收录情况： SCI

摘要： Lipidomics is a rapidly-growing field which focuses on global characterization of lipids at molecular and systems levels. As small changes in the concentrations of lipids may have important physiological consequences, much attention in the field has recently been paid to more accurate quantitation and identification of lipids. Community-wide efforts have been initiated, aiming to develop best practices for lipidomic analyses and reporting of lipidomic data. Nevertheless, current approaches for comprehensive analysis of lipidomes have some inherent challenges and limitations. Additionally, there is, currently, limited knowledge concerning the impacts of various external and internal exposures on lipid levels. In this review, we discuss the recent progress in lipidomics analysis, with a primary focus on analytical approaches, as well as on the different sources of variation in quantifying lipid levels, both technical and biological. (c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序