Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels

文献类型： 外文期刊

第一作者： Zhang, Xiaopei

作者： Zhang, Xiaopei;Wang, Wei;Dong, Jie;Cheng, Yingying;Shen, Fafu;Zhu, Weidong;Yin, Zujun

作者机构：

关键词： lncRNA; epigenetic; transcriptional; post-transcriptional; translation; post-translational modification

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN：

年卷期： 2019 年 20 卷 22 期

页码：

收录情况： SCI

摘要： Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways. They play important roles in biological processes such as chromatin remodeling, transcriptional activation, transcriptional interference, RNA processing, and mRNA translation. lncRNAs have important functions in plant growth and development; biotic and abiotic stress responses; and in regulation of cell differentiation, the cell cycle, and the occurrence of many diseases in humans and animals. In this review, we summarize the functions and mechanisms of lncRNAs in plants, humans, and animals at different regulatory levels.

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