Rice-derived peptide AAGALPS inhibits TNF-alpha-induced inflammation and oxidative stress in vascular endothelial cells

文献类型： 外文期刊

第一作者： Tong, Li-Tao

作者： Tong, Li-Tao;Ju, Zhiyuan;Liu, Liya;Wang, Lili;Zhou, Xianrong;Xiao, Tianzhen;Zhou, Sumei

作者机构：

关键词： HUVEC; inflammation; oxidative stress; rice peptide; TNF-alpha

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2020 年 8 卷 1 期

页码：

收录情况： SCI

摘要： Injury of vascular endothelial cell is one of the main factors triggering atherosclerosis. Peptide AAGALPS was derived from digestion and absorption product of rice alpha-globulin, which was proved to prevent atherosclerosis in previous study. This study aims to investigate the potential effects of AAGALPS on improving tumor necrosis factor-alpha (TNF-alpha)-stimulated human umbilical vein endothelial cells' (HUVECs) injury. As a result, the viability of HUVECs stimulated by tumor necrosis factor-alpha was significantly increased by AAGALPS in a dose-dependent manner until 25 mu g/ml. The peptide obviously reduced the levels of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, nitric oxide, inducible nitric oxide synthase, reactive oxygen species, and malondialdehyde and increased the concentrations of glutathione peroxidase. Furthermore, AAGALPS inhibited the nuclear factor kappa B (NF-kappa B) activation and nuclear translocation through regulating inhibitor of nuclear factor kappa B kinase alpha and inhibitor of NF-kappa B. These results indicated that AAGALPS protected vascular endothelial cells through mediating inflammation and oxidative stress.

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