Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis

文献类型： 外文期刊

第一作者： Cao, Liyan

作者： Cao, Liyan;Xue, Mei;Chen, Jianfei;Shi, Hongyan;Zhang, Xin;Shi, Da;Liu, Jianbo;Huang, Liping;Wei, Yanwu;Liu, Changming;Feng, Li

作者机构：

关键词： Porcine parvovirus; Endoplasmic reticulum stress; Unfolded protein response; Protein kinase R-like ER kinase pathway; Apoptotic cell death

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2020 年 539 卷

页码：

收录情况： SCI

摘要： Endoplasmic reticulum (ER) stress is associated with numerous mammalian diseases, especially viral diseases. Porcine parvovirus (PPV) is the causative agent of reproductive failure in swine. Here, we observed that the PPV infection of porcine kidney 15 and porcine testis cells resulted in the activation of ER stress sensors mediated by protein kinase R-like ER kinase (PERK), but not inositol-requiring enzyme 1 and activating transcription factor 6 (ATF6). ER stress activation obviously blocked PPV replication. Depletion of proteins, such as PERK, eukaryotic initiation factor 2, and ATF4, by small interfering RNA significantly enhanced PPV replication. Moreover, the pro-apoptotic factor C/EBP homologous protein was identified a key factor in the inhibition of PPV replication. These data demonstrate that PPV infection activates ER stress through the PERK signaling pathway and that ER stress inhibits further PPV replication by promoting apoptosis.

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