Effects of dietary supplementation with l-arginine on the intestinal barrier function in finishing pigs with heat stress

文献类型： 外文期刊

第一作者： Yi, Hongbo

作者： Yi, Hongbo;Xiong, Yunxia;Wu, Qiwen;Wang, Mengzhu;Liu, Shuai;Jiang, Zongyong;Wang, Li

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关键词： finishing pigs; heat stress; intestinal barrier function; intestinal morphology; l-Arginine

期刊名称：JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION （ 影响因子：2.13； 五年影响因子：2.322 ）

ISSN： 0931-2439

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收录情况： SCI

摘要： Previous studies showed heat stress reduces body weight gain and feed intake associated with damaged intestinal barrier function, and l-arginine (L-Arg) enhanced intestinal barrier function in young animals under stress. The aim of this study was to evaluate effects of L-Arg on serum hormones, intestinal morphology, nutrients absorption and epithelial barrier functions in finishing pigs with heat stress. Forty-eight finishing pigs (Landrace) were balanced for sex and then randomly assigned to six groups: TN group, thermal neutral (22 degrees C, 80% humidity) with a basal diet; HS group, heat stress (cyclical 35 degrees C for 12 hr and 22 degrees C for 12 hr, 80% humidity) with a basal diet; PF group, thermal neutral (22 degrees C, 80% humidity) and pair-fed with the HS; the TNA, HSA and PFA groups were the basal diet of TN group, HS group and PF group supplemented with 1% L-Arg. Results showed that HS decreased (p < .05) the thyroxine concentrations and increased (p < .05) the insulin concentrations in serum compared with the TN group, but 1% L-Arg had no significant effects on them. Both HS and PF significantly increased (p < .05) the mRNA expression of cationic amino acid transporters (CAT1 and CAT2) and decreased the mRNA expression of solute carrier family 5 member 10 (SGLT1) in the jejunum compared with the TN group. Compared with the TN group, HS reduced the expression of tight junction (TJ) protein zonula occluden-1 (ZO-1) and occludin, but PF only decreased ZO-1 expression in the jejunum. Results exhibited that dietary supplementation with 1% L-Arg improved the intestinal villous height, the ratio of villous height to crypt depth, and the expression of occludin and porcine beta-defensin 2 (pBD2) in the jejunum of intermittent heat-treated finishing pigs. In conclusion, dietary supplementation with 1% L-Arg could partly attenuate the intermittent heat-induced damages of intestinal morphology and epithelial barrier functions in finishing pigs.

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